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Applied and Environmental Microbiology, October 2005, p. 6434-6437, Vol. 71, No. 10
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.10.6434-6437.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Aquaporin Expression and Freeze Tolerance in Candida albicans

An Tanghe,1* Jennifer M. Carbrey,2 Peter Agre,2 Johan M. Thevelein,1 and Patrick Van Dijck1

Laboratorium voor Moleculaire Celbiologie and Vlaams Interuniversitair Instituut voor Biotechnologie, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium,1 Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-211852

Received 4 March 2005/ Accepted 1 June 2005

Aquaporins are members of the major intrinsic protein superfamily of integral membrane proteins which enable the transport of water, glycerol, and other solutes across membranes in various organisms. In microorganisms, the physiological role of aquaporins is not yet defined. We found a clear correlation between expression of the Candida albicans aquaporin-encoding gene AQY1 and freeze tolerance. A connection with the function for the aquaporin in the natural environment of C. albicans is, however, not obvious.


* Corresponding author. Mailing address: Laboratorium voor Moleculaire Celbiologie and Vlaams Interuniversitair Instituut voor Biotechnologie, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium. Phone: 32-16-32 86 33. Fax: 32-16-32 19 79. E-mail: An.Tanghe{at}bio.kuleuven.be.


Applied and Environmental Microbiology, October 2005, p. 6434-6437, Vol. 71, No. 10
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.10.6434-6437.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.