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Applied and Environmental Microbiology, November 2005, p. 6934-6946, Vol. 71, No. 11
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.11.6934-6946.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identifying Components of the NF-{kappa}B Pathway in the Beneficial Euprymna scolopes-Vibrio fischeri Light Organ Symbiosis{dagger}

Michael S. Goodson,1 Mila Kojadinovic,1,{ddagger} Joshua V. Troll,1 Todd E. Scheetz,2 Thomas L. Casavant,2,3 M. Bento Soares,4 and Margaret J. McFall-Ngai1*

Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706,1 Center for Bioinformatics and Computational Biology and Departments of Biomedical Engineering and Opthalmology,2 Department of Electrical and Computer Engineering,3 Department of Pediatrics, University of Iowa, Iowa City, Iowa 522424

Received 1 April 2005/ Accepted 1 July 2005

The Toll/NF-{kappa}B pathway is a common, evolutionarily conserved innate immune pathway that modulates the responses of animal cells to microbe-associated molecular patterns (MAMPs). Because MAMPs have been implicated as critical elements in the signaling of symbiont-induced development, an expressed sequence tag library from the juvenile light organ of Euprymna scolopes was used to identify members of the Toll/NF-{kappa}B pathway. Full-length transcripts were identified by using 5' and 3' RACE PCR. Seven transcripts critical for MAMP-induced triggering of the Toll/NF-{kappa}B phosphorylation cascade have been identified, including receptors, signal transducers, and a transcription factor. Further investigations should elucidate the role of the Toll/NF-{kappa}B pathway in the initiation of the beneficial symbiosis between E. scolopes and Vibrio fischeri.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of Wisconsin, 1300 University Ave., Madison, WI 53706. Phone: (608) 262-2393. Fax: (608) 262-8418. E-mail: mjmcfallngai{at}wisc.edu.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

{ddagger} Present address: CEA Cadarache DEVM/LBC-Bat 156, 13108 Saint Paul-Lez-Durance Cedex, France.

Applied and Environmental Microbiology, November 2005, p. 6934-6946, Vol. 71, No. 11
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.11.6934-6946.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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