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Applied and Environmental Microbiology, November 2005, p. 7613-7617, Vol. 71, No. 11
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.11.7613-7617.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Bacteriocin (Mutacin) Production by Streptococcus mutans Genome Sequence Reference Strain UA159: Elucidation of the Antimicrobial Repertoire by Genetic Dissection

John D. F. Hale, Yi-Tian Ting, Ralph W. Jack, John R. Tagg, and Nicholas C. K. Heng*

Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin, New Zealand

Received 29 November 2004/ Accepted 30 June 2005

Streptococcus mutans UA159, the genome sequence reference strain, exhibits nonlantibiotic mutacin activity. In this study, bioinformatic and mutational analyses were employed to demonstrate that the antimicrobial repertoire of strain UA159 includes mutacin IV (specified by the nlm locus) and a newly identified bacteriocin, mutacin V (encoded by SMU.1914c).

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin, New Zealand. Phone: 64 3 479-5155. Fax: 64 3 479-8540. E-mail: nicholas.heng{at}stonebow.otago.ac.nz.

Applied and Environmental Microbiology, November 2005, p. 7613-7617, Vol. 71, No. 11
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.11.7613-7617.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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