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Applied and Environmental Microbiology, December 2005, p. 8558-8564, Vol. 71, No. 12
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.12.8558-8564.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Inhibition of Helicobacter pylori and Associated Urease by Oregano and Cranberry Phytochemical Synergies

Y. T. Lin, Y. I. Kwon, R. G. Labbe, and K. Shetty*

Department of Food Science, Chenoweth Laboratory, University of Massachusetts, Amherst, Massachusetts 01003

Received 8 May 2005/ Accepted 13 September 2005

Ulcer-associated dyspepsia is caused by infection with Helicobacter pylori. H. pylori is linked to a majority of peptic ulcers. Antibiotic treatment does not always inhibit or kill H. pylori with potential for antibiotic resistance. The objective of this study was to determine the potential for using phenolic phytochemical extracts to inhibit H. pylori in a laboratory medium. Our approach involved the development of a specific phenolic profile with optimization of different ratios of extract mixtures from oregano and cranberry. Subsequently, antimicrobial activity and antimicrobial-linked urease inhibition ability were evaluated. The results indicated that the antimicrobial activity was greater in extract mixtures than in individual extracts of each species. The results also indicate that the synergistic contribution of oregano and cranberry phenolics may be more important for inhibition than any species-specific phenolic concentration. Further, based on plate assay, the likely mode of action may be through urease inhibition and disruption of energy production by inhibition of proline dehydrogenase at the plasma membrane.

* Corresponding author. Mailing address: Department of Food Science, Chenoweth Laboratory, University of Massachusetts, Amherst, MA01003. Phone: (413) 545-1022. Fax: (413) 545-1262. E-mail: kalidas{at}foodsci.umass.edu.

Applied and Environmental Microbiology, December 2005, p. 8558-8564, Vol. 71, No. 12
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.12.8558-8564.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Brown, J. C., Huang, G., Haley-Zitlin, V., Jiang, X. (2009). Antibacterial Effects of Grape Extracts on Helicobacter pylori. Appl. Environ. Microbiol. 75: 848-852 [Abstract] [Full Text]  


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