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Applied and Environmental Microbiology, December 2005, p. 8995-8997, Vol. 71, No. 12
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.12.8995-8997.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Rapid Detection of Subtype-Selective Nuclear Hormone Receptor Binding with Bacterial Genetic Selection

Georgios Skretas1 and David W. Wood1,2*

Department of Chemical Engineering,1 Department of Molecular Biology, Princeton University, Princeton, New Jersey 085442

Received 12 July 2005/ Accepted 12 September 2005

Subtype-selective nuclear hormone receptor modulators could potentially allow the development of valuable tissue-specific therapeutics. A simple biosensor that allows subtype-specific nuclear hormone receptor binding to be reflected by the growth phenotype of Escherichia coli cells has been constructed. This system will potentially enable the facile detection or evolution of subtype-selective hormone analogues.

* Corresponding author. Mailing address: Department of Chemical Engineering, Princeton University, Engineering Quadrangle, Olden St., Princeton, NJ 08544. Phone: (609) 258-5721. Fax: (609) 258-0211. E-mail: dwood{at}princeton.edu.

Applied and Environmental Microbiology, December 2005, p. 8995-8997, Vol. 71, No. 12
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.12.8995-8997.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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