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Applied and Environmental Microbiology, August 2005, p. 4938-4940, Vol. 71, No. 8
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.8.4938-4940.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Farnesol Concentrations Required To Block Germ Tube Formation in Candida albicans in the Presence and Absence of Serum

Daniel D. Mosel, Raluca Dumitru, Jacob M. Hornby,{dagger} Audrey L. Atkin, and Kenneth W. Nickerson*

School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666

Received 5 February 2005/ Accepted 11 March 2005

Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 µM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 µM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

* Corresponding author. Mailing address: School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0666. Phone: (402) 472-2253. Fax: (402) 472-8722. E-mail: knickerson1{at}unl.edu.

{dagger} Present address: Division of Natural Sciences, Lewis-Clark State College, Lewiston, ID 83501.

Applied and Environmental Microbiology, August 2005, p. 4938-4940, Vol. 71, No. 8
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.8.4938-4940.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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