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Applied and Environmental Microbiology, September 2005, p. 5577-5581, Vol. 71, No. 9
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.9.5577-5581.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Disintegration of Staphylococcus epidermidis Biofilms under Glucose-Limiting Conditions Depends on the Activity of the Alternative Sigma Factor {sigma}B{dagger}

Sebastian Jäger,1 Dietrich Mack,1,2 Holger Rohde,1 Matthias A. Horstkotte,1 and Johannes K.-M. Knobloch1*

Institut für Infektionsmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany,1 Department of Medical Microbiology and Infectious Diseases, School of Medicine, University of Wales Swansea, Swansea SA2 8PP, United Kingdom2

Received 14 October 2004/ Accepted 6 April 2005

To evaluate the role of the polysaccharide intercellular adhesin as an energy-storage molecule, we investigated the effect of nutrient limitation on S. epidermidis biofilms. The stability of established biofilms depends on {sigma}B activity; however, the slow decay of biofilms under conditions of nutrient limitation reveal its use as an energy-storage molecule to be unlikely.

* Corresponding author. Mailing address: Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin I, Institut für Infektionsmedizin, Martinistr. 52, D-20246 Hamburg, Germany. Phone: 49-40-42803-3147. Fax: 49-40-42803-4881. E-mail: knobloch{at}uke.uni-hamburg.de.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, September 2005, p. 5577-5581, Vol. 71, No. 9
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.9.5577-5581.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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