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Applied and Environmental Microbiology, January 2006, p. 946-949, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.946-949.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Butyrate Specifically Down-Regulates Salmonella Pathogenicity Island 1 Gene Expression

I. Gantois,1* R. Ducatelle,1 F. Pasmans,1 F. Haesebrouck,1 I. Hautefort,2 A. Thompson,2 J. C. Hinton,2 and F. Van Immerseel1

Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium,1 Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom2

Received 12 August 2005/ Accepted 5 October 2005

Invasion of intestinal epithelial cells by Salmonella enterica is decreased after exposure to butyric acid. To understand the molecular mechanisms of this phenomenon, a comparative transcriptomic analysis of Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium grown in medium supplemented with butyrate was performed. We found that butyrate down-regulated the expression of 19 genes common to both serovars by a factor of twofold or more, and 17 of these genes localized to the Salmonella pathogenicity island 1 (SPI1). These included the SPI1 regulatory genes hilD and invF. Of the remaining two genes, ampH has 91% homology to an Escherichia coli penicillin-binding protein and sopE2 encodes a type III-secreted effector protein associated with invasion but located at a separate site on the chromosome from SPI1.

* Corresponding author. Mailing address: Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Phone: (32) 09 264 77 40. Fax: (32) 09 264 77 89. E-mail: inne.gantois{at}UGent.be

Applied and Environmental Microbiology, January 2006, p. 946-949, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.946-949.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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