This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gantois, I.
Right arrow Articles by Van Immerseel, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gantois, I.
Right arrow Articles by Van Immerseel, F.
Agricola
Right arrow Articles by Gantois, I.
Right arrow Articles by Van Immerseel, F.

 Previous Article  |  Next Article 

Applied and Environmental Microbiology, January 2006, p. 946-949, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.946-949.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Butyrate Specifically Down-Regulates Salmonella Pathogenicity Island 1 Gene Expression

I. Gantois,1* R. Ducatelle,1 F. Pasmans,1 F. Haesebrouck,1 I. Hautefort,2 A. Thompson,2 J. C. Hinton,2 and F. Van Immerseel1

Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium,1 Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom2

Received 12 August 2005/ Accepted 5 October 2005

Invasion of intestinal epithelial cells by Salmonella enterica is decreased after exposure to butyric acid. To understand the molecular mechanisms of this phenomenon, a comparative transcriptomic analysis of Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium grown in medium supplemented with butyrate was performed. We found that butyrate down-regulated the expression of 19 genes common to both serovars by a factor of twofold or more, and 17 of these genes localized to the Salmonella pathogenicity island 1 (SPI1). These included the SPI1 regulatory genes hilD and invF. Of the remaining two genes, ampH has 91% homology to an Escherichia coli penicillin-binding protein and sopE2 encodes a type III-secreted effector protein associated with invasion but located at a separate site on the chromosome from SPI1.

* Corresponding author. Mailing address: Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Phone: (32) 09 264 77 40. Fax: (32) 09 264 77 89. E-mail: inne.gantois{at}UGent.be

Applied and Environmental Microbiology, January 2006, p. 946-949, Vol. 72, No. 1
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.1.946-949.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Herold, S., Paton, J. C., Srimanote, P., Paton, A. W. (2009). Differential effects of short-chain fatty acids and iron on expression of iha in Shiga-toxigenic Escherichia coli. Microbiology 155: 3554-3563 [Abstract] [Full Text]  
  • Teirlynck, E., Haesebrouck, F., Pasmans, F., Dewulf, J., Ducatelle, R., Van Immerseel, F. (2009). The cereal type in feed influences Salmonella Enteritidis colonization in broilers. Poult. Sci. 88: 2108-2112 [Abstract] [Full Text]  
  • Garner, C. D., Antonopoulos, D. A., Wagner, B., Duhamel, G. E., Keresztes, I., Ross, D. A., Young, V. B., Altier, C. (2009). Perturbation of the Small Intestine Microbial Ecology by Streptomycin Alters Pathology in a Salmonella enterica Serovar Typhimurium Murine Model of Infection. Infect. Immun. 77: 2691-2702 [Abstract] [Full Text]  
  • Fernandez-Rubio, C., Ordonez, C., Abad-Gonzalez, J., Garcia-Gallego, A., Honrubia, M. P., Mallo, J. J., Balana-Fouce, R. (2009). Butyric acid-based feed additives help protect broiler chickens from Salmonella Enteritidis infection. Poult. Sci. 88: 943-948 [Abstract] [Full Text]  
  • Eeckhaut, V., Van Immerseel, F., Dewulf, J., Pasmans, F., Haesebrouck, F., Ducatelle, R., Courtin, C. M., Delcour, J. A., Broekaert, W. F. (2008). Arabinoxylooligosaccharides from Wheat Bran Inhibit Salmonella Colonization in Broiler Chickens. Poult. Sci. 87: 2329-2334 [Abstract] [Full Text]  
  • Huang, Y., Suyemoto, M., Garner, C. D., Cicconi, K. M., Altier, C. (2008). Formate Acts as a Diffusible Signal To Induce Salmonella Invasion. J. Bacteriol. 190: 4233-4241 [Abstract] [Full Text]  
  • Lim, S., Yun, J., Yoon, H., Park, C., Kim, B., Jeon, B., Kim, D., Ryu, S. (2007). Mlc regulation of Salmonella pathogenicity island I gene expression via hilE repression. Nucleic Acids Res 35: 1822-1832 [Abstract] [Full Text]  
  • Morgan, E., Bowen, A. J., Carnell, S. C., Wallis, T. S., Stevens, M. P. (2007). SiiE Is Secreted by the Salmonella enterica Serovar Typhimurium Pathogenicity Island 4-Encoded Secretion System and Contributes to Intestinal Colonization in Cattle. Infect. Immun. 75: 1524-1533 [Abstract] [Full Text]  
  • Nagy, G., Danino, V., Dobrindt, U., Pallen, M., Chaudhuri, R., Emody, L., Hinton, J. C., Hacker, J. (2006). Down-Regulation of Key Virulence Factors Makes the Salmonella enterica Serovar Typhimurium rfaH Mutant a Promising Live-Attenuated Vaccine Candidate.. Infect. Immun. 74: 5914-5925 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»