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Applied and Environmental Microbiology, December 2006, p. 7941-7944, Vol. 72, No. 12
0099-2240/06/$08.00+0     doi:10.1128/AEM.01277-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Isolation of Two Polyketide Synthase Gene Fragments from the Uncultured Microbial Symbiont of the Marine Bryozoan Bugula neritina{triangledown}

Nicole B. Lopanik,1* Nancy M. Targett,1 and Niels Lindquist2

Graduate College of Marine Studies, University of Delaware, 700 Pilottown Road, Lewes, Delaware 19958,1 Institute of Marine Sciences, University of North Carolina at Chapel Hill, 3431 Arendell Street, Morehead City, North Carolina 285572

Received 3 June 2006/ Accepted 17 September 2006

"Candidatus Endobugula sertula," the uncultured microbial symbiont of the bryozoan Bugula neritina, produces ecologically and biomedically important polyketide metabolites called bryostatins. We isolated two gene fragments from B. neritina larvae that have high levels of similarity to polyketide synthase genes. These gene fragments are clearly associated with the symbiont and not with the host.

* Corresponding author. Present address: Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216. Phone: (734) 647-8988. Fax: (734) 615-3641. E-mail: nlopanik{at}umich.edu.

{triangledown} Published ahead of print on 22 September 2006.

Applied and Environmental Microbiology, December 2006, p. 7941-7944, Vol. 72, No. 12
0099-2240/06/$08.00+0     doi:10.1128/AEM.01277-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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