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Applied and Environmental Microbiology, February 2006, p. 1700-1701, Vol. 72, No. 2
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.2.1700-1701.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Caenorhabditis elegans Is a Model Host for Listeria monocytogenes

Line E. Thomsen,1 Sandra S. Slutz,2 Man-Wah Tan,2 and Hanne Ingmer1*

Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University (KVL), Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark,1 Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-51202

Received 6 October 2005/ Accepted 11 December 2005

Here we report that Caenorhabditis elegans nematodes fed Listeria monocytogenes die over the course of several days, as a consequence of an accumulation of bacteria in the worm intestine. Mutant strains previously shown to be important for virulence in mammalian models were also found to be attenuated in their virulence in C. elegans. However, ActA, which is required for actin-based intracellular motility, appears to be dispensable during infection of C. elegans, indicating that L. monocytogenes remains extracellular in C. elegans.

* Corresponding author. Mailing address: Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University (KVL), Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark. Phone: 45 35282773. Fax: 45 35282755. E-mail: hi{at}kvl.dk.

Applied and Environmental Microbiology, February 2006, p. 1700-1701, Vol. 72, No. 2
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.2.1700-1701.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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