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Applied and Environmental Microbiology, March 2006, p. 2260-2264, Vol. 72, No. 3
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.3.2260-2264.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Casein-Derived Antimicrobial Peptides Generated by Lactobacillus acidophilus DPC6026

M. Hayes,1,2 R. P. Ross,1,3 G. F. Fitzgerald,2,3 C. Hill,2,3 and C. Stanton1,3*

Teagasc, Moorepark Food Research Centre, Fermoy, Cork, Ireland,1 Department of Microbiology, University College, Cork, Ireland,2 Alimentary Pharmabiotic Centre, Cork, Ireland3

Received 15 September 2005/ Accepted 24 December 2005

Three peptides produced by a Lactobacillus acidophilus DPC6026 fermentation of sodium caseinate and showing antibacterial activity against pathogenic strains Enterobacter sakazakii ATCC 12868 and Escherichia coli DPC5063 were characterized. These peptides were all generated from bovine {alpha}s1-casein and identified as IKHQGLPQE, VLNENLLR, and SDIPNPIGSENSEK. These peptides may have bioprotective applicability and potential use in milk-based formula, which has been linked to E. sakazakii infection in neonates.

* Corresponding author. Mailing address: Teagasc, Biotechnology Centre, Moorepark, Fermoy, Co. Cork, Ireland. Phone: 353 25 42222. Fax: 353 25 42340. E-mail: catherine.stanton{at}teagasc.ie.

Applied and Environmental Microbiology, March 2006, p. 2260-2264, Vol. 72, No. 3
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.3.2260-2264.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hayes, M., Stanton, C., Slattery, H., O'Sullivan, O., Hill, C., Fitzgerald, G. F., Ross, R. P. (2007). Casein Fermentate of Lactobacillus animalis DPC6134 Contains a Range of Novel Propeptide Angiotensin-Converting Enzyme Inhibitors. Appl. Environ. Microbiol. 73: 4658-4667 [Abstract] [Full Text]  


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