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Applied and Environmental Microbiology, April 2006, p. 3050-3053, Vol. 72, No. 4
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.4.3050-3053.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Safety Assessment of the Oral Cavity Probiotic Streptococcus salivarius K12

Jeremy P. Burton,1,2* Philip A. Wescombe,1 Chris J. Moore,1 Chris N. Chilcott,1 and John R. Tagg1,2

BLIS Technologies Ltd.,1 Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand2

Received 11 October 2005/ Accepted 9 January 2006

Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12.

* Corresponding author. Mailing address: BLIS Technologies, Centre for Innovation, University of Otago, P.O. Box 56, Dunedin, New Zealand. Phone: 64 3 479 3061. Fax: 64 3 479 8954. E-mail: jeremy.burton{at}blis.co.nz.

Applied and Environmental Microbiology, April 2006, p. 3050-3053, Vol. 72, No. 4
0099-2240/06/$08.00+0     doi:10.1128/AEM.72.4.3050-3053.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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