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Applied and Environmental Microbiology, June 2006, p. 4472-4474, Vol. 72, No. 6
0099-2240/06/$08.00+0     doi:10.1128/AEM.02519-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Reduction of Acid Tolerance by Tetracycline in Escherichia coli Expressing tetA(C) Is Reversed by Cations

Kai F. Hung,1 Jeffrey J. Byrd,2 Jeffrey L. Bose,1,{dagger} and Charles W. Kaspar1*

Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin—Madison, Madison, Wisconsin,1 Department of Biology, St. Mary's College of Maryland, St. Mary's City, Maryland2

Received 25 October 2005/ Accepted 26 March 2006

When tetracycline was present, tetA(C) reduced acid tolerance, suppressed rpoS expression, and increased the concentration of total soluble proteins in stationary-phase Escherichia coli. The suppression of acid tolerance was reversed by 85 mM sodium, potassium, magnesium, and calcium ions but not by 85 mM sucrose. Implications for using TetA(C) are discussed.

* Corresponding author. Mailing address: University of Wisconsin, 1925 Willow Dr., Madison, WI 53706-1187. Phone: (608) 263-6936. Fax: (608) 263-1114. E-mail: cwkaspar{at}wisc.edu.

{dagger} Present address: Department of Microbiology, University of Georgia—Athens, Athens, GA 30602.

Applied and Environmental Microbiology, June 2006, p. 4472-4474, Vol. 72, No. 6
0099-2240/06/$08.00+0     doi:10.1128/AEM.02519-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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