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Applied and Environmental Microbiology, June 2006, p. 4497-4499, Vol. 72, No. 6
0099-2240/06/$08.00+0     doi:10.1128/AEM.02515-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

In Vitro Fermentation of Breast Milk Oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri

Robert E. Ward,1 Milady Niñonuevo,2 David A. Mills,3 Carlito B. Lebrilla,2 and J. Bruce German1,4

Departments of Food Science and Technology,1 Chemistry,2 Viticulture and Enology, University of California, Davis, California 95616, and Nestlé Research Centre, Lausanne, Switzerland,3 Nestlé Research Centre, Lausanne, Switzerland4

Received 25 October 2005/ Accepted 26 March 2006

It has been proposed that human milk oligosaccharides (HMO) function as a prebiotic for bifidobacteria, yet this activity has not been adequately investigated. In this study, Bifidobacterium infantis was shown to ferment purified HMO as a sole carbon source, while another gut commensal, Lactobacillus gasseri, did not ferment HMO. Our results support the hypothesis that HMO selectively amplify bacterial populations in the infant intestine.

* Corresponding author. Mailing address: Department of Food Science and Technology, University of California, Davis, CA 95616. Phone: (530) 752-1486. Fax: (530) 752-4759. E-mail: jbgerman{at}ucdavis.edu.

Applied and Environmental Microbiology, June 2006, p. 4497-4499, Vol. 72, No. 6
0099-2240/06/$08.00+0     doi:10.1128/AEM.02515-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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