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Applied and Environmental Microbiology, July 2006, p. 4638-4647, Vol. 72, No. 7
0099-2240/06/$08.00+0     doi:10.1128/AEM.00184-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Phase-Variable Surface Structures Are Required for Infection of Campylobacter jejuni by Bacteriophages

Chris Coward,1,{dagger} Andrew J. Grant,1*,{dagger} Craig Swift,2 Jennifer Philp,1 Rebecca Towler,1 Mohammad Heydarian,1 Jennifer A. Frost,3 and Duncan J. Maskell1

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom,1 Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW9 5HT, United Kingdom,2 Welsh Assembly Government, Cathays Park, Cardiff, Wales CF10 3NQ, United Kingdom3

Received 24 January 2006/ Accepted 18 April 2006

This study characterizes the interaction between Campylobacter jejuni and the 16 phages used in the United Kingdom typing scheme by screening spontaneous mutants of the phage-type strains and transposon mutants of the sequenced strain NCTC 11168. We show that the 16 typing phages fall into four groups based on their patterns of activity against spontaneous mutants. Screens of transposon and defined mutants indicate that the phage-bacterium interaction for one of these groups appears to involve the capsular polysaccharide (CPS), while two of the other three groups consist of flagellatropic phages. The expression of CPS and flagella is potentially phase variable in C. jejuni, and the implications of these findings for typing and intervention strategies are discussed.

* Corresponding author. Mailing address: University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES, United Kingdom. Phone: 441223765811. Fax: 441223337610. E-mail: ajg60{at}cam.ac.uk.

{dagger} C.C. and A.J.G. contributed equally to this study.

Applied and Environmental Microbiology, July 2006, p. 4638-4647, Vol. 72, No. 7
0099-2240/06/$08.00+0     doi:10.1128/AEM.00184-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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Copyright © 2006 by the American Society for Microbiology. All rights reserved.