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Applied and Environmental Microbiology, July 2006, p. 5100-5103, Vol. 72, No. 7
0099-2240/06/$08.00+0     doi:10.1128/AEM.01934-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Colonization Dynamics of Altered Schaedler Flora Is Influenced by Gender, Aging, and Helicobacter hepaticus Infection in the Intestines of Swiss Webster Mice

Zhongming Ge,1* Yang Feng,1 Nancy S. Taylor,1 Masahiro Ohtani,1 Martin F. Polz,2 David B. Schauer,1 and James G. Fox1

Division of Comparative Medicine,1 Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 021392

Received 16 August 2005/ Accepted 11 May 2006

The distribution and colonization levels of the altered Schaedler flora (ASF) in their natural hosts are poorly understood. Intestinal colonization levels of the eight ASF strains in outbred Swiss Webster mice with or without Helicobacter hepaticus infection were characterized by real-time quantitative PCR. All ASF strains were detected in the cecum and colon, but some strains displayed significant variation in colonization levels with host age, gender, and H. hepaticus infection status.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, 16-873, 77 Massachusetts Avenue, Cambridge, MA 02139. Phone: (617) 253-5518. Fax: (617) 258-5708. E-mail: zge{at}mit.edu.

Applied and Environmental Microbiology, July 2006, p. 5100-5103, Vol. 72, No. 7
0099-2240/06/$08.00+0     doi:10.1128/AEM.01934-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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