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Applied and Environmental Microbiology, July 2006, p. 5135-5137, Vol. 72, No. 7
0099-2240/06/$08.00+0     doi:10.1128/AEM.00611-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Caenorhabditis elegans Senses Bacterial Autoinducers

Elmus Beale,1 Guigen Li,3 Man-Wah Tan,4 and Kendra P. Rumbaugh2*

Departments of Cell Biology and Biochemistry,1 Surgery, Texas Tech University Health Sciences Center,2 Department of Biochemistry, Texas Tech University, Lubbock, Texas 79430,3 Department of Genetics, Stanford University School of Medicine, Stanford, California 943054

Received 15 March 2006/ Accepted 25 April 2006

Pseudomonas aeruginosa uses virulence factors controlled by quorum sensing (QS) to kill Caenorhabditis elegans. Here we show that C. elegans is attracted to the acylated homoserine lactones (AHSLs) that mediate QS in P. aeruginosa. Our data also indicate that C. elegans can distinguish AHSLs and may use them to mediate aversive or attractive learning.

* Corresponding author. Mailing address: Texas Tech University Health Sciences Center, Department of Surgery, 3601 4th Street, Lubbock, TX 79430. Phone: (806) 743-2460, ext. 264. Fax: (806) 743-2370. E-mail: kendra.rumbaugh{at}ttuhsc.edu.

Applied and Environmental Microbiology, July 2006, p. 5135-5137, Vol. 72, No. 7
0099-2240/06/$08.00+0     doi:10.1128/AEM.00611-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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