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Applied and Environmental Microbiology, August 2006, p. 5615-5617, Vol. 72, No. 8
0099-2240/06/$08.00+0     doi:10.1128/AEM.00722-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Survival of Lactobacillus casei in the Human Digestive Tract after Consumption of Fermented Milk

Raish Oozeer,1,{dagger} Antony Leplingard,2,{dagger} Denis D. G. Mater,1,{ddagger} Agnès Mogenet,3 Rachel Michelin,1 Isabelle Seksek,2 Philippe Marteau,4 Joël Doré,1 Jean-Louis Bresson,4 and Gérard Corthier1*

Unité d'Ecologie et de Physiologie du Système Digestif, INRA, 78350 Jouy en Josas, France,1 Danone Vitapole, 91767 Palaiseau, France,2 Centre d'Investigation Clinique AP-HP/INSERM, Université René Descartes and Hôpital Necker-Enfants Malades, 75015 Paris, France,3 Service de Gastro-Entérologie, Université René Descartes and Hôpital Européen Georges Pompidou, 75908 Paris, France4

Received 29 March 2006/ Accepted 9 May 2006

A human trial was carried out to assess the ileal and fecal survival of Lactobacillus casei DN-114 001 ingested in fermented milk. Survival rates were up to 51.2% in the ileum and 28.4% in the feces. The probiotic bacterium has the capacity to survive during its transit through the human gut.

* Corresponding author. Mailing address: National Institute of Agronomic Research, UEPSD, CRJ, INRA, Batiment 440, 78350 Jouy en Josas, France. Phone: 33-134 652 467. Fax: 33-1 34 65 24 62. E-mail: gerard.corthier{at}jouy.inra.fr.

{dagger} R. Oozeer and A. Leplingard contributed equally to this work.

{ddagger} Present address: Syndifrais, 42 rue de Châteaudun, 75314 Paris cedex 09, France.

Applied and Environmental Microbiology, August 2006, p. 5615-5617, Vol. 72, No. 8
0099-2240/06/$08.00+0     doi:10.1128/AEM.00722-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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