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Applied and Environmental Microbiology, August 2006, p. 5623-5625, Vol. 72, No. 8
0099-2240/06/$08.00+0     doi:10.1128/AEM.00538-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

The Lactic Acid-Induced Acid Tolerance Response in Salmonella enterica Serovar Typhimurium Induces Sensitivity to Hydrogen Peroxide{dagger}

E. J. Greenacre,* S. Lucchini, J. C. D. Hinton, and T. F. Brocklehurst

Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom

Received 7 March 2006/ Accepted 17 May 2006

Transcriptome analyses of Salmonella enterica serovar Typhimurium revealed that 15 genes were significantly up-regulated after 2 h of adaptation with lactic acid. cadB was the most highly up-regulated gene and was shown to be an essential component. Lactic acid-adapted cells exhibited sensitivity to hydrogen peroxide, likely due to down-regulation of the OxyR regulon.

* Corresponding author. Mailing address: Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom. Phone: 44 (0)1603 255216. Fax: 44 (0)1603 507723. E-mail: elizabeth.greenacre{at}bbsrc.ac.uk.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, August 2006, p. 5623-5625, Vol. 72, No. 8
0099-2240/06/$08.00+0     doi:10.1128/AEM.00538-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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Copyright © 2006 by the American Society for Microbiology. All rights reserved.