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Applied and Environmental Microbiology, August 2006, p. 5670-5672, Vol. 72, No. 8
0099-2240/06/$08.00+0     doi:10.1128/AEM.00609-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Production of Resveratrol in Recombinant Microorganisms

Jules Beekwilder,* Rianne Wolswinkel, Harry Jonker, Robert Hall, C. H. Ric de Vos, and Arnaud Bovy

Plant Research International, P.O. Box 16, 6700 AA Wageningen, The Netherlands

Received 15 March 2006/ Accepted 16 June 2006

Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter).

* Corresponding author. Mailing address: Plant Research International, P.O. Box 16, 6700 AA Wageningen, The Netherlands. Phone: 31-317-477001. Fax: 31-317-418094. E-mail: Jules.Beekwilder{at}wur.nl.

Applied and Environmental Microbiology, August 2006, p. 5670-5672, Vol. 72, No. 8
0099-2240/06/$08.00+0     doi:10.1128/AEM.00609-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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