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Applied and Environmental Microbiology, July 2007, p. 4691-4694, Vol. 73, No. 14
0099-2240/07/$08.00+0     doi:10.1128/AEM.00496-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Alpha-Agarases Define a New Family of Glycoside Hydrolases, Distinct from Beta-Agarase Families

Didier Flament, Tristan Barbeyron, Murielle Jam, Philippe Potin, Mirjam Czjzek, Bernard Kloareg, and Gurvan Michel^*

Centre National de la Recherche Scientifique, Université Pierre et Marie Curie-Paris6, Unité Mixte de Recherche 7139, Station Biologique, F-29682 Roscoff Cedex, Bretagne, France

Received 5 March 2007/ Accepted 12 May 2007

The gene encoding the -agarase from "Alteromonas agarilytica" (proposed name) has been cloned and sequenced. The gene product (154 kDa) is unrelated to ß-agarases and instead belongs to a new family of glycoside hydrolases (GH96). The -agarase also displays a complex modularity, with the presence of five thrombospondin type 3 repeats and three carbohydrate-binding modules.

Published ahead of print on 18 May 2007.

Present address: UMR 6197 (IFREMER/CNRS), Laboratoire de Microbiologie et Environnements Extremes, Plouzane, Bretagne, France.