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Applied and Environmental Microbiology, August 2007, p. 5058-5065, Vol. 73, No. 15
0099-2240/07/$08.00+0     doi:10.1128/AEM.00453-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Responses of Wild-Type and Resistant Strains of the Hyperthermophilic Bacterium Thermotoga maritima to Chloramphenicol Challenge{triangledown} ,{dagger}

Clemente I. Montero,{ddagger} Matthew R. Johnson,§ Chung-Jung Chou, Shannon B. Conners, Sarah G. Geouge, Sabrina Tachdjian, Jason D. Nichols, and Robert M. Kelly*

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905

Received 27 February 2007/ Accepted 3 June 2007

Transcriptomes and growth physiologies of the hyperthermophile Thermotoga maritima and an antibiotic-resistant spontaneous mutant were compared prior to and following exposure to chloramphenicol. While the wild-type response was similar to that of mesophilic bacteria, reduced susceptibility of the mutant was attributed to five mutations in 23S rRNA and phenotypic preconditioning to chloramphenicol.

* Corresponding author. Mailing address: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905. Phone: (919) 515-6396. Fax: (919) 515-3465. E-mail: rmkelly{at}eos.ncsu.edu

{triangledown} Published ahead of print on 8 June 2007.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

{ddagger} Present address: National Institutes of Health, Bethesda, MD 20892.

§ Present address: Wyeth Pharmaceuticals, Sanford, NC 27330.

Present address: SAS Corporation, Cary, NC 27513.

Applied and Environmental Microbiology, August 2007, p. 5058-5065, Vol. 73, No. 15
0099-2240/07/$08.00+0     doi:10.1128/AEM.00453-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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