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Responses of Wild-Type and Resistant Strains of the Hyperthermophilic Bacterium Thermotoga maritima to Chloramphenicol Challenge ^,

Clemente I. Montero, Matthew R. Johnson, Chung-Jung Chou, Shannon B. Conners,^¶ Sarah G. Geouge, Sabrina Tachdjian, Jason D. Nichols, and Robert M. Kelly^*

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905

Received 27 February 2007/ Accepted 3 June 2007

Transcriptomes and growth physiologies of the hyperthermophile Thermotoga maritima and an antibiotic-resistant spontaneous mutant were compared prior to and following exposure to chloramphenicol. While the wild-type response was similar to that of mesophilic bacteria, reduced susceptibility of the mutant was attributed to five mutations in 23S rRNA and phenotypic preconditioning to chloramphenicol.

Published ahead of print on 8 June 2007.

Supplemental material for this article may be found at http://aem.asm.org/.

Present address: National Institutes of Health, Bethesda, MD 20892.

Present address: Wyeth Pharmaceuticals, Sanford, NC 27330.

^¶ Present address: SAS Corporation, Cary, NC 27513.