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Applied and Environmental Microbiology, August 2007, p. 5370-5373, Vol. 73, No. 16
0099-2240/07/$08.00+0     doi:10.1128/AEM.00807-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

New Enzymatic Method of Chiral Amino Acid Synthesis by Dynamic Kinetic Resolution of Amino Acid Amides: Use of Stereoselective Amino Acid Amidases in the Presence of {alpha}-Amino-{varepsilon}-Caprolactam Racemase{triangledown}

Shigenori Yamaguchi, Hidenobu Komeda, and Yasuhisa Asano*

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan

Received 11 April 2007/ Accepted 9 June 2007

D- and L-amino acids were produced from L- and D-amino acid amides by D-aminopeptidase from Ochrobactrum anthropi C1-38 and L-amino acid amidase from Pseudomonas azotoformans IAM 1603, respectively, in the presence of {alpha}-amino-{varepsilon}-caprolactam racemase from Achromobacter obae as the catalyst by dynamic kinetic resolution of amino acid amides.

* Corresponding author. Mailing address: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. Phone: 81 766 56 7500, ext. 530. Fax: 81 766 56 2498. E-mail: asano{at}pu-toyama.ac.jp

{triangledown} Published ahead of print on 22 June 2007.

Applied and Environmental Microbiology, August 2007, p. 5370-5373, Vol. 73, No. 16
0099-2240/07/$08.00+0     doi:10.1128/AEM.00807-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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