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Applied and Environmental Microbiology, September 2007, p. 5951-5953, Vol. 73, No. 18
0099-2240/07/$08.00+0     doi:10.1128/AEM.01067-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Potential Use of Toxic Thermolabile Proteins To Study Protein Quality Control Systems{triangledown}

Itzhak Mizrahi, Michael Dagan, Dvora Biran, and Eliora Z. Ron*

Department of Molecular Microbiology and Biotechnology, Life Sciences, Tel Aviv University, Tel Aviv, Israel 69978

Received 26 April 2007/ Accepted 13 July 2007

SulA is an Escherichia coli division inhibitor with a short half-life whose accumulation results in filamentation. Here, we show that SulA is thermally unstable and forms aggregates at elevated temperatures. This property enables the selection of isolates with mutated protein quality control systems.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Biotechnology, Life Sciences, Tel Aviv University, Tel Aviv, Israel 69978. Phone: 972-3-6409379. Fax: 972-3-6414138. E-mail: eliora{at}post.tau.ac.il

{triangledown} Published ahead of print on 20 July 2007.

Applied and Environmental Microbiology, September 2007, p. 5951-5953, Vol. 73, No. 18
0099-2240/07/$08.00+0     doi:10.1128/AEM.01067-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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