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Applied and Environmental Microbiology, November 2007, p. 7103-7109, Vol. 73, No. 21
0099-2240/07/$08.00+0     doi:10.1128/AEM.01117-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Fate of the Two-Component Lantibiotic Lacticin 3147 in the Gastrointestinal Tract{triangledown}

Gillian E. Gardiner,1,2 Mary C. Rea,1,2 Brid O'Riordan,1 Paula O'Connor,1,2 Sheila M. Morgan,1,2 Peadar G. Lawlor,3 P. Brendan Lynch,3 Michael Cronin,4 R. Paul Ross,1,2* and Colin Hill2

Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland,1 Alimentary Pharmabiotic Centre, University College, Cork, Ireland,2 Teagasc, Pig Production Development Unit, Moorepark Research Centre, Fermoy, County Cork, Ireland,3 Department of Statistics, University College, Cork, Ireland4

Received 18 May 2007/ Accepted 17 August 2007

The component peptides of lacticin 3147 were degraded by {alpha}-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.

* Corresponding author. Mailing address: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland. Phone: 353 25 42229. Fax: 353 25 42340. E-mail: paul.ross{at}teagasc.ie

{triangledown} Published ahead of print on 31 August 2007.

Applied and Environmental Microbiology, November 2007, p. 7103-7109, Vol. 73, No. 21
0099-2240/07/$08.00+0     doi:10.1128/AEM.01117-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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