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Applied and Environmental Microbiology, December 2007, p. 7781-7784, Vol. 73, No. 23
0099-2240/07/$08.00+0     doi:10.1128/AEM.01247-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Nisin-Controlled Extracellular Production of Interleukin-2 in Lactococcus lactis Strains, without the Requirement for a Signal Peptide Sequence{triangledown}

Antonio Fernández,1* Juan M. Rodríguez,2 Roy J. Bongaerts,1 Michael J. Gasson,1 and Nikki Horn1

Commensals & Microflora, BBSRC Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom,1 Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain2

Received 5 June 2007/ Accepted 19 September 2007

Secretion of the cytokine interleukin-2 (IL-2) was investigated in Lactococcus lactis using the secretory machinery of the bacteriocin lactococcin A. Surprisingly, the lcnCD transport genes were not essential for mouse IL-2 secretion. Furthermore, expression of a mature mouse IL-2 gene resulted in interleukin secretion without the requirement for a leader sequence.

* Corresponding author. Mailing address: Commensals & Microflora, BBSRC Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom. Phone: 441603-255397. Fax: 441603-255288. E-mail: antonio.dumont{at}bbsrc.ac.uk

{triangledown} Published ahead of print on 28 September 2007.

Applied and Environmental Microbiology, December 2007, p. 7781-7784, Vol. 73, No. 23
0099-2240/07/$08.00+0     doi:10.1128/AEM.01247-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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