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Applied and Environmental Microbiology, February 2007, p. 1010-1013, Vol. 73, No. 3
0099-2240/07/$08.00+0     doi:10.1128/AEM.01675-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Chronic Helicobacter pylori Infection Does Not Significantly Alter the Microbiota of the Murine Stomach{triangledown} ,{dagger}

Mai Ping Tan,1,2,3 Maria Kaparakis,1,2 Maja Galic,1,2 John Pedersen,4 Martin Pearse,5 Odilia L. C. Wijburg,1,2,3 Peter H. Janssen,1 and Richard A. Strugnell1,2,3*

Department of Microbiology and Immunology,1 Australian Bacterial Pathogenesis Program,2 Cooperative Research Centre for Vaccine Technology, University of Melbourne, Melbourne, Victoria 3010, Australia,3 Tissupath Pty. Ltd., Melbourne, Victoria 3122, Australia,4 CSL Limited, Melbourne, Victoria 3052, Australia5

Received 19 July 2006/ Accepted 20 November 2006

We examined the impact of Helicobacter pylori infection on the murine gastric microbiota by culture and terminal-restriction fragment length polymorphism and found that neither acute nor chronic H. pylori infection substantially affected the gastric microbial composition. Interestingly, the total H. pylori burden detected by real-time PCR was significantly higher than that revealed by viable counts, suggesting that the antigenic load sustaining H. pylori-induced gastritis could be considerably higher than previously believed.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia. Phone: 61 (3) 8344-5712. Fax: 61 (3) 9347-1540. E-mail: rastru{at}unimelb.edu.au.

{triangledown} Published ahead of print on 1 December 2006.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, February 2007, p. 1010-1013, Vol. 73, No. 3
0099-2240/07/$08.00+0     doi:10.1128/AEM.01675-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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