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Applied and Environmental Microbiology, February 2007, p. 1146-1152, Vol. 73, No. 4
0099-2240/07/$08.00+0     doi:10.1128/AEM.01891-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora{triangledown}

Paul R. Jensen,* Philip G. Williams, Dong-Chan Oh, Lisa Zeigler, and William Fenical

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204

Received 8 August 2006/ Accepted 3 December 2006

Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to the genus Salinispora. The pattern emerged in a study that included global collection sites, and it indicates that secondary metabolite production can be a species-specific, phenotypic trait associated with broadly distributed bacterial populations. Associations between actinomycete phylotype and chemotype revealed an effective, diversity-based approach to natural product discovery that contradicts the conventional wisdom that secondary metabolite production is strain specific. The structural diversity of the metabolites observed, coupled with gene probing and phylogenetic analyses, implicates lateral gene transfer as a source of the biosynthetic genes responsible for compound production. These results conform to a model of selection-driven pathway fixation occurring subsequent to gene acquisition and provide a rare example in which demonstrable physiological traits have been correlated to the fine-scale phylogenetic architecture of an environmental bacterial community.

* Corresponding author. Mailing address: Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204. Phone: (858) 534-7322. Fax: (858) 558-3703. E-mail: pjensen{at}ucsd.edu.

{triangledown} Published ahead of print on 8 December 2006.

Applied and Environmental Microbiology, February 2007, p. 1146-1152, Vol. 73, No. 4
0099-2240/07/$08.00+0     doi:10.1128/AEM.01891-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Udwary, D. W., Zeigler, L., Asolkar, R. N., Singan, V., Lapidus, A., Fenical, W., Jensen, P. R., Moore, B. S. (2007). Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Natl. Acad. Sci. USA 104: 10376-10381 [Abstract] [Full Text]  


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