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Applied and Environmental Microbiology, May 2007, p. 3095-3097, Vol. 73, No. 9
0099-2240/07/$08.00+0     doi:10.1128/AEM.02809-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Thiols in Nitric Oxide Synthase-Containing Nocardia sp. Strain NRRL 5646{triangledown}

Sungwon Lee,1 Hélène Bergeron,2 Peter C. K. Lau,2 and John P. N. Rosazza1*

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Center for Biocatalysis and Bioprocessing, The University of Iowa, Iowa City, Iowa 52242,1 Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Ave., Montreal, Quebec H4P 2R2, Canada2

Received 1 December 2006/ Accepted 19 February 2007

Mycothiol (MSH) [1-D-myo-inosityl-2-(N-acetyl-L-cysteinyl)amido-2-deoxy-{alpha}-D-glucopyranoside], isolated as the bimane derivative, was established to be the major thiol in Nocardia sp. strain NRRL 5646, a species most closely related to Nocardia brasiliensis strain DSM 43758T. Thiol formation and detection of MSH-dependent formaldehyde dehydrogenase activity in cell extracts are relevant to the possible modulation of nitric oxide toxicity generated by strain NRRL 5646.

* Corresponding author. Mailing address: Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Center for Biocatalysis and Bioprocessing, The University of Iowa, Iowa City, IA 52242. Phone: (319) 335-4900. Fax: (319) 335-8766. E-mail: john-rosazza{at}uiowa.edu

{triangledown} Published ahead of print on 2 March 2007.

Applied and Environmental Microbiology, May 2007, p. 3095-3097, Vol. 73, No. 9
0099-2240/07/$08.00+0     doi:10.1128/AEM.02809-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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