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Applied and Environmental Microbiology, June 2008, p. 3596-3600, Vol. 74, No. 11
0099-2240/08/$08.00+0     doi:10.1128/AEM.02842-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Aspergillus nidulans Natural Product Biosynthesis Is Regulated by MpkB, a Putative Pheromone Response Mitogen-Activated Protein Kinase{triangledown} ,{dagger}

Ali Atoui, Dapeng Bao, Navgeet Kaur, W. Scott Grayburn, and Ana M. Calvo*

Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115

Received 17 December 2007/ Accepted 21 March 2008

The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters.

* Corresponding author. Mailing address: Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115. Phone: (815) 753-0451. Fax: (815) 753-0461. E-mail: amcalvo{at}niu.edu

{triangledown} Published ahead of print on 31 March 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, June 2008, p. 3596-3600, Vol. 74, No. 11
0099-2240/08/$08.00+0     doi:10.1128/AEM.02842-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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