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Applied and Environmental Microbiology, July 2008, p. 4222-4225, Vol. 74, No. 13
0099-2240/08/$08.00+0     doi:10.1128/AEM.02874-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Discovery of a Modified Transcription Factor Endowing Yeasts with Organic-Solvent Tolerance and Reconstruction of an Organic-Solvent-Tolerant Saccharomyces cerevisiae Strain{triangledown}

Ken Matsui, Shinya Teranishi, Shohei Kamon, Kouichi Kuroda, and Mitsuyoshi Ueda*

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan

Received 20 December 2007/ Accepted 27 April 2008

Organic-solvent tolerance in Saccharomyces cerevisiae strain KK-211, which was first isolated as an organic-solvent-tolerant strain, depends on point mutation (R821S) of the transcription factor Pdr1p. The integration of the PDR1 R821S mutation into wild-type yeast results in organic-solvent tolerance, and the PDR1 R821S mutant can reduce carbonyl compounds in organic solvents.

* Corresponding author. Mailing address: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan. Phone: 81-75-7536110. Fax: 81-75-7536112. E-mail: miueda{at}kais.kyoto-u.ac.jp

{triangledown} Published ahead of print on 9 May 2008.

Applied and Environmental Microbiology, July 2008, p. 4222-4225, Vol. 74, No. 13
0099-2240/08/$08.00+0     doi:10.1128/AEM.02874-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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