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Applied and Environmental Microbiology, July 2008, p. 4550-4552, Vol. 74, No. 14
0099-2240/08/$08.00+0     doi:10.1128/AEM.00391-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Explosive-Degrading Cytochrome P450 System Is Highly Conserved among Strains of Rhodococcus spp.

Helena M. B. Seth-Smith ,^2,, James Edwards,^1,, Susan J. Rosser,^2, Deborah A. Rathbone,¹ and Neil C. Bruce^1,2*

CNAP, Department of Biology, University of York, York YO10 5WY, United Kingdom,¹ Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1TJ, United Kingdom²

Received 15 February 2008/ Accepted 10 May 2008

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a widely used explosive and a serious environmental pollutant. Nineteen strains of Rhodococcus spp. capable of utilizing RDX as the sole nitrogen source have been isolated. The cytochrome P450 system XplA-XplB, which is responsible for RDX breakdown, is present in 18 of these strains.

Published ahead of print on 16 May 2008.

Present address: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom.

H.M.B.S.-S. and J.E. contributed equally to this paper.

Present address: Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.