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 Previous Article

Applied and Environmental Microbiology, July 2008, p. 4585-4588, Vol. 74, No. 14
0099-2240/08/$08.00+0     doi:10.1128/AEM.00083-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Temperature-Dependent Parasitic Relationship between Legionella pneumophila and a Free-Living Amoeba (Acanthamoeba castellanii){triangledown}

Akira Ohno,1* Naoyuki Kato,2 Ryota Sakamoto,1,3 Soichiro Kimura,1 and Keizo Yamaguchi1

Departments of Microbiology and Infectious Disease,1 Chemistry, Faculty of Medicine, Toho University, Tokyo,2 Department of Public Health, Kyoto University School of Medicine, Kyoto, Japan3

Received 11 January 2008/ Accepted 19 May 2008

We analyzed the effects of temperature on the interaction of Legionella pneumophila with Acanthamoeba castellanii. At <20°C, overexpression of type 1 metacaspase, a stimulator of A. castellanii encystation, was associated with a reduced number of bacteria within amoeba. At low temperatures, A. castellanii seems to eliminate L. pneumophila by encystation and digestion.

* Corresponding author. Mailing address: Department of Microbiology and Infectious Disease, Faculty of Medicine, Toho University, 5-21-16 Omori-Nishi, Ota-Ku, Tokyo 143-8540, Japan. Phone: 81 (3) 3762-4151. Fax: 81 (3) 5493-5415. E-mail: akira{at}med.toho-u.ac.jp

{triangledown} Published ahead of print on 23 May 2008.

Applied and Environmental Microbiology, July 2008, p. 4585-4588, Vol. 74, No. 14
0099-2240/08/$08.00+0     doi:10.1128/AEM.00083-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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