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Applied and Environmental Microbiology, August 2008, p. 4768-4771, Vol. 74, No. 15
0099-2240/08/$08.00+0     doi:10.1128/AEM.00117-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Transcriptome Analysis of the Lactococcus lactis ArgR and AhrC Regulons{triangledown}

Rasmus Larsen,1,{dagger} Sacha A. F. T. van Hijum,1 Jan Martinussen,2 Oscar P. Kuipers,1 and Jan Kok1*

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands,1 Bacterial Physiology and Genetics, BioCentrum-DTU, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark2

Received 14 January 2008/ Accepted 27 May 2008

In previous studies, we have shown that direct protein-protein interaction between the two regulators ArgR and AhrC in Lactococcus lactis is required for arginine-dependent repression of the biosynthetic argC promoter and the activation of the catabolic arcA promoter. Here, we establish the global ArgR and AhrC regulons by transcriptome analyses and show that both regulators are dedicated to the control of arginine metabolism in L. lactis.

* Corresponding author. Mailing address: Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands. Phone: 31-50-3632111. Fax: 31-50-3632348. E-mail: jan.kok{at}rug.nl

{triangledown} Published ahead of print on 6 June 2008.

{dagger} Present address: Inflammation Group, Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.

Applied and Environmental Microbiology, August 2008, p. 4768-4771, Vol. 74, No. 15
0099-2240/08/$08.00+0     doi:10.1128/AEM.00117-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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