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Applied and Environmental Microbiology, August 2008, p. 4776-4778, Vol. 74, No. 15
0099-2240/08/$08.00+0     doi:10.1128/AEM.00136-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Improvement of Lactobacillus plantarum Aerobic Growth as Directed by Comprehensive Transcriptome Analysis{triangledown} ,{dagger}

Marc J. A. Stevens,1,2,3 Anne Wiersma,1,2 Willem M. de Vos,1,3 Oscar P. Kuipers,4 Eddy J. Smid,1,2 Douwe Molenaar,1,2 and Michiel Kleerebezem1,2,3*

TI Food and Nutrition, P.O. Box 557, 6700 AN Wageningen, The Netherlands,1 NIZO food research, P.O. Box 20, 6710 BA Ede, The Netherlands,2 Laboratory of Microbiology, Wageningen University and Research Centre, Dreijenplein 10, 6703 HB Wageningen, The Netherlands,3 Department of Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Rijksuniversiteit Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands4

Received 15 January 2008/ Accepted 4 April 2008

An aerobic Lactobacillus plantarum culture displayed growth stagnation during early growth. Transcriptome analysis revealed that resumption of growth after stagnation correlated with activation of CO2-producing pathways, suggesting that a limiting CO2 concentration induced the stagnation. Analogously, increasing the CO2 gas partial pressure during aerobic fermentation prevented the temporal growth stagnation.

* Corresponding author. Mailing address: NIZO food research, P.O. Box 20, 6710 BA Ede, The Netherlands. Phone: 31-(0)318-659629. Fax: 31-(0)318-650400. E-mail: Michiel.kleerebezem{at}nizo.nl

{triangledown} Published ahead of print on 6 June 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, August 2008, p. 4776-4778, Vol. 74, No. 15
0099-2240/08/$08.00+0     doi:10.1128/AEM.00136-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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