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Applied and Environmental Microbiology, September 2008, p. 5832-5837, Vol. 74, No. 18
0099-2240/08/$08.00+0     doi:10.1128/AEM.00893-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Escherichia coli Constructs Expressing Human or Porcine Enterotoxins Induce Identical Diarrheal Diseases in a Piglet Infection Model{triangledown}

Weiping Zhang,1* Donald C. Robertson,2 Chengxian Zhang,1 Wei Bai,1 Mojun Zhao,1 and David H. Francis1

The Center for Infectious Disease Research & Vaccinology, Department of Veterinary Science, South Dakota State University, Brookings, South Dakota,1 Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, Kansas2

Received 18 April 2008/ Accepted 13 July 2008

To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.

* Corresponding author. Mailing address: The Center for Infectious Disease Research & Vaccinology, South Dakota State University, Box 2175, North Campus Drive, Brookings, SD 57007. Phone: (605) 688-4317. Fax: (605) 688-6003. E-mail: weiping.zhang{at}sdstate.edu

{triangledown} Published ahead of print on 25 July 2008.

Applied and Environmental Microbiology, September 2008, p. 5832-5837, Vol. 74, No. 18
0099-2240/08/$08.00+0     doi:10.1128/AEM.00893-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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