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Applied and Environmental Microbiology, October 2008, p. 6147-6150, Vol. 74, No. 19
0099-2240/08/$08.00+0     doi:10.1128/AEM.00516-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Transformation of N-Phenylpiperazine by Mixed Cultures from a Municipal Wastewater Treatment Plant{triangledown}

Carina M. Jung,1 Thomas M. Heinze,2 Joanna Deck,1 Ruth Strakosha,1,{dagger} and John B. Sutherland1*

Divisions of Microbiology,1 Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas2

Received 3 March 2008/ Accepted 28 July 2008

Samples from a wastewater treatment plant were used as inocula for mixed cultures dosed with N-phenylpiperazine (NPP), a model compound containing the piperazine ring found in many fluoroquinolones. Chemical analyses showed that NPP (50 mg liter–1) disappeared in 12 days, with the appearance of a transient metabolite and two nitrosated compounds.

* Corresponding author. Mailing address: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079. Phone: (870) 543-7059. Fax: (870) 543-7307. E-mail: john.sutherland{at}fda.hhs.gov

{triangledown} Published ahead of print on 1 August 2008.

{dagger} Present address: Department of Molecular Biology and Microbiology, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826.

Applied and Environmental Microbiology, October 2008, p. 6147-6150, Vol. 74, No. 19
0099-2240/08/$08.00+0     doi:10.1128/AEM.00516-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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