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Applied and Environmental Microbiology, October 2008, p. 6155-6157, Vol. 74, No. 19
0099-2240/08/$08.00+0     doi:10.1128/AEM.01017-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Presence of icaADBC Is Detrimental to the Colonization of Human Skin by Staphylococcus epidermidis{triangledown}

K. L. Rogers,1 M. E. Rupp,2 and P. D. Fey1*

Departments of Pathology and Microbiology,1 Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska2

Received 6 May 2008/ Accepted 29 July 2008

Previous studies have demonstrated that Staphylococcus epidermidis isolates colonizing the skin of healthy humans do not typically encode icaADBC, the genes responsible for the production of polysaccharide intercellular adhesin or biofilms. It was therefore hypothesized that the presence of icaADBC was deleterious to the successful colonization of human skin by S. epidermidis. Using a human skin competition model, it was determined that the strong biofilm-producing S. epidermidis strain 1457 was outcompeted at 1, 3, and 10 days by an isogenic icaADBC mutant (1457 ica::dhfr), suggesting a fitness cost for carriage of icaADBC.

* Corresponding author. Mailing address: University of Nebraska Medical Center, 986280 Nebraska Medical Center, Omaha, NE 68198-6280. Phone: (402) 559-2122. Fax: (402) 559-4077. E-mail: pfey{at}unmc.edu

{triangledown} Published ahead of print on 8 August 2008.

Applied and Environmental Microbiology, October 2008, p. 6155-6157, Vol. 74, No. 19
0099-2240/08/$08.00+0     doi:10.1128/AEM.01017-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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