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The BaeSR Two-Component Regulatory System Mediates Resistance to Condensed Tannins in Escherichia coli ^,

Erwin G. Zoetendal,^1, Alexandra H. Smith,^2* Monica A. Sundset,^1,3 and Roderick I. Mackie¹

Department of Animal Sciences and Division of Nutritional Sciences, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois,¹ Agtech Products Inc., Waukesha, Wisconsin,² Department of Arctic Biology and Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway³

Received 5 October 2007/ Accepted 13 November 2007

The gene expression profiles of Escherichia coli strains grown anaerobically with or without Acacia mearnsii (black wattle) extract were compared to identify tannin resistance strategies. The cell envelope stress protein gene spy and the multidrug transporter-encoding operon mdtABCD, both under the control of the BaeSR two-component regulatory system, were significantly up-regulated in the presence of tannins. BaeSR mutants were more tannin sensitive than their wild-type counterparts.

Published ahead of print on 26 November 2007.

Supplemental material for this article may be found at http://aem.asm.org/.

Current address: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands.