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Applied and Environmental Microbiology, October 2008, p. 6206-6215, Vol. 74, No. 20
0099-2240/08/$08.00+0     doi:10.1128/AEM.01053-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Identification and Characterization of Lactococcal-Prophage-Carried Superinfection Exclusion Genes{triangledown} ,{dagger}

Jennifer Mahony,1 Stephen McGrath,1 Gerald F. Fitzgerald,1,2 and Douwe van Sinderen1,2*

Department of Microbiology,1 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland2

Received 10 May 2008/ Accepted 15 August 2008

Superinfection exclusion (Sie) proteins are prophage-encoded phage resistance systems. In this study, genes encoding Sie systems were identified on the genomes of Lactococcus lactis subsp. cremoris MG1363 and L. lactis subsp. lactis IL1403. These Sie systems are genetically distinct and yet were shown to act specifically against a particular subset of the 936 phage group. Each of the systems allows normal phage adsorption while affecting plasmid transduction and intracellular phage DNA replication, which points to the blocking of phage DNA injection as their common mode of action. Sie-specifying genes found on the MG1363 prophages are also present in various lactococcal strains, whereas the prophage-encoded Sie systems of IL1403 do not appear to be as widely disseminated.

* Corresponding author. Mailing address: Department of Microbiology, University College Cork, Western Road, Cork, Ireland. Phone: 353 21 4901365. Fax: 353 21 4903101. E-mail: d.vansinderen{at}ucc.ie

{triangledown} Published ahead of print on 22 August 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, October 2008, p. 6206-6215, Vol. 74, No. 20
0099-2240/08/$08.00+0     doi:10.1128/AEM.01053-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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