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Applied and Environmental Microbiology, November 2008, p. 6792-6796, Vol. 74, No. 21
0099-2240/08/$08.00+0     doi:10.1128/AEM.01124-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of a Variant of Bacillus anthracis-Specific Phage AP50 with Improved Bacteriolytic Activity{triangledown} ,{dagger}

Shanmuga Sozhamannan,1* Michael McKinstry,1 Shannon M. Lentz,1 Matti Jalasvuori,2 Farrell McAfee,1 Angela Smith,1 Jason Dabbs,1 Hans-W. Ackermann,3 Jaana K. H. Bamford,2 Alfred Mateczun,1 and Timothy D. Read1

Naval Medical Research Center, Silver Spring, Maryland 20910,1 Department of Biological and Environmental Science and Nanoscience Center, P.O. Box 35, 40104-University of Jyväskylä, Jyväskylä, Finland,2 Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Quebec, Canada G1K 7P43

Received 19 May 2008/ Accepted 29 August 2008

The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype.

* Corresponding author. Mailing address: Genomics Department, Biological Defense Research Directorate Annex, Naval Medical Research Center, 12300 Washington Avenue, Rockville, MD 20852. Phone: (301) 231-6713. Fax: (301) 231-6799. E-mail: Shanmuga.Sozhamannan{at}med.navy.mil

{triangledown} Published ahead of print on 12 September 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, November 2008, p. 6792-6796, Vol. 74, No. 21
0099-2240/08/$08.00+0     doi:10.1128/AEM.01124-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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