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Applied and Environmental Microbiology, December 2008, p. 7437-7438, Vol. 74, No. 23
0099-2240/08/$08.00+0     doi:10.1128/AEM.01019-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes{triangledown} ,{dagger}

Faping Duan, Katherine L. Curtis, and John C. March*

Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853

Received 6 May 2008/ Accepted 26 September 2008

Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml–1 of insulin with no significant background secretion.

* Corresponding author. Mailing address: 220 Riley Robb Hall, Ithaca, NY 14853. Phone: (607) 254-5471. Fax: (607) 255-4080. E-mail: jcm224{at}cornell.edu

{triangledown} Published ahead of print on 3 October 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, December 2008, p. 7437-7438, Vol. 74, No. 23
0099-2240/08/$08.00+0     doi:10.1128/AEM.01019-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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