This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wagner, B. A.
Right arrow Articles by Dargatz, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wagner, B. A.
Right arrow Articles by Dargatz, D. A.
Agricola
Right arrow Articles by Wagner, B. A.
Right arrow Articles by Dargatz, D. A.

 Previous Article  |  Next Article 

Applied and Environmental Microbiology, March 2008, p. 1731-1739, Vol. 74, No. 6
0099-2240/08/$08.00+0     doi:10.1128/AEM.01132-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effect of Antimicrobial Dosage Regimen on Salmonella and Escherichia coli Isolates from Feeder Swine{triangledown}

Bruce A. Wagner,1* Barbara E. Straw,2 Paula J. Fedorka-Cray,3 and David A. Dargatz1

Centers for Epidemiology and Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Fort Collins, Colorado 80526-8117,1 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824,2 Bacterial Epidemiology and Antimicrobial Resistance Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Athens, Georgia 306053

Received 21 May 2007/ Accepted 11 January 2008

A body of evidence exists that suggests that antimicrobial use in food animals leads to resistance in both pathogenic and commensal bacteria. This study focused on the impact of three different antimicrobial regimes (low-level continuous, pulse, and no antimicrobial) for two antimicrobials (chlortetracycline and tylosin) on the presence of Salmonella spp. and on the prevalence of antimicrobial resistance of both Salmonella spp. and nonspecific Escherichia coli in fecal samples from feeder swine. The prevalence of fecal samples positive for Salmonella spp. significantly decreased between the samples taken at feeder placement compared to samples taken when the animals were close to market weight. Differences in resistance of Salmonella spp. did not appear to be influenced by dosing treatment including the control. Analysis of antimicrobial resistance examining both susceptibility and resistance, as well as MIC outcomes, demonstrated that only resistance to cephalothin increased in E. coli under the pulse chlortetracycline treatment. These results suggest that the dosing regimes examined in this study did not lead to an increase in either the prevalence of Salmonella spp. or the prevalence of antimicrobial resistance in isolates of Salmonella spp. or E. coli.

* Corresponding author. Mailing address: Centers for Epidemiology and Animal Health, 2150 Centre Avenue, Bldg. B, Fort Collins, CO 80526. Phone: (970) 494-7256. Fax: (970) 494-7228. E-mail: bruce.a.wagner{at}aphis.usda.gov

{triangledown} Published ahead of print on 25 January 2008.

Applied and Environmental Microbiology, March 2008, p. 1731-1739, Vol. 74, No. 6
0099-2240/08/$08.00+0     doi:10.1128/AEM.01132-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»