AEM
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AEM.02334-07v1
74/6/1932    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Papadopoulos, C. J.
Right arrow Articles by Riley, T. V.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Papadopoulos, C. J.
Right arrow Articles by Riley, T. V.
Agricola
Right arrow Articles by Papadopoulos, C. J.
Right arrow Articles by Riley, T. V.

 Previous Article  |  Next Article 

Applied and Environmental Microbiology, March 2008, p. 1932-1935, Vol. 74, No. 6
0099-2240/08/$08.00+0     doi:10.1128/AEM.02334-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of the MexAB-OprM Efflux Pump of Pseudomonas aeruginosa in Tolerance to Tea Tree (Melaleuca alternifolia) Oil and Its Monoterpene Components Terpinen-4-ol, 1,8-Cineole, and {alpha}-Terpineol{triangledown}

Chelsea J. Papadopoulos,1 Christine F. Carson,1* Barbara J. Chang,1 and Thomas V. Riley1,2

Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia,1 Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia2

Received 29 September 2007/ Accepted 3 January 2008

Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and {alpha}-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.

* Corresponding author. Mailing address: Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia. Phone: 61 8 9346 3288. Fax: 61 8 9346 2912. E-mail: ccarson{at}cyllene.uwa.edu.au

{triangledown} Published ahead of print on 11 January 2008.

Applied and Environmental Microbiology, March 2008, p. 1932-1935, Vol. 74, No. 6
0099-2240/08/$08.00+0     doi:10.1128/AEM.02334-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Microbiol. Mol. Biol. Rev. Eukaryot. Cell All ASM Journals

Copyright © 2008 by the American Society for Microbiology. All rights reserved.