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Applied and Environmental Microbiology, April 2008, p. 2248-2253, Vol. 74, No. 7
0099-2240/08/$08.00+0     doi:10.1128/AEM.01998-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Inhibition of Species of the Aspergillus Section Nigri and Ochratoxin A Production in Grapes by Fusapyrone{triangledown}

Mara Favilla,1 Michelangelo Pascale,1 Alessandra Ricelli,1 Antonio Evidente,2 Carmine Amalfitano,2 and Claudio Altomare1*

Institute of Sciences of Food Production, CNR, 70125 Bari, Italy,1 Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente, e delle Produzioni Animali, Università di Napoli Federico II, 80055 Portici, Italy2

Received 31 August 2007/ Accepted 30 January 2008

Fusapyrone (FP), an antifungal natural compound, was tested against the three main ochratoxigenic species of the Aspergillus section Nigri. The MICs at 24 h were 6.0, 11.6, and 9.9 µg/ml for Aspergillus carbonarius, Aspergillus tubingensis, and Aspergillus niger, respectively. Strong inhibition of growth and morphological changes were still observed at half the MIC after 7 days. The application of a 100 µg/ml FP solution in a laboratory assay on artificially inoculated grapes resulted in a significant reduction (up to 6 orders of magnitude) of A. carbonarius CFU counts. Dramatic reductions of the ochratoxin A (OTA) content, compared to the content of the positive control (average amount of OTA, 112.5 ng/g of grape; three experiments), were obtained with the application of either 100 or 50 µg/ml of FP (0.6 or 5.1 ng/g of grape, respectively).

* Corresponding author. Mailing address: Istituto di Scienze delle Produzioni Alimentari, CNR, Via Giovanni Amendola 122/O, 70125 Bari, Italy. Phone: 39 80 592 9318. Fax: 39 80 592 9374. E-mail: claudio.altomare{at}ispa.cnr.it

{triangledown} Published ahead of print on 8 February 2008.

Applied and Environmental Microbiology, April 2008, p. 2248-2253, Vol. 74, No. 7
0099-2240/08/$08.00+0     doi:10.1128/AEM.01998-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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