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Applied and Environmental Microbiology, January 2009, p. 261-264, Vol. 75, No. 1
0099-2240/09/$08.00+0     doi:10.1128/AEM.00261-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Oxygen-Mediated Regulation of Biofilm Development Is Controlled by the Alternative Sigma Factor {sigma}B in Staphylococcus epidermidis{triangledown}

John J. Cotter,1 James P. O'Gara,2 Dietrich Mack,3 and Eoin Casey1*

UCD School of Chemical and Bioprocess Engineering, Centre for Synthesis and Chemical Biology,1 UCD School of Biomedical and Biomolecular Science, University College Dublin, Belfield, Dublin 4, Ireland,2 Medical Microbiology and Infectious Diseases, Institute of Life Science, School of Medicine, Swansea University, Swansea, Wales, United Kingdom3

Received 30 January 2008/ Accepted 17 October 2008

Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of {sigma}B. Under anaerobic conditions, increased {sigma}B activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.

* Corresponding author. Mailing address: UCD School of Chemical and Bioprocess Engineering, Engineering and Materials Science Centre, University College Dublin, Belfield, Dublin 4, Ireland. Phone: 353 1 7161877. Fax: 353 1 7161177. E-mail: eoin.casey{at}ucd.ie

{triangledown} Published ahead of print on 14 November 2008.

Applied and Environmental Microbiology, January 2009, p. 261-264, Vol. 75, No. 1
0099-2240/09/$08.00+0     doi:10.1128/AEM.00261-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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