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Applied and Environmental Microbiology, January 2009, p. 275-280, Vol. 75, No. 1
0099-2240/09/$08.00+0     doi:10.1128/AEM.01734-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Plasmid-Encoded Regulator Activates Factors Conferring Lysozyme Resistance on Enteropathogenic Escherichia coli Strains{triangledown}

Nina Salinger, Bashkim Kokona, Robert Fairman, and Iruka N. Okeke*

Department of Biology, Haverford College, 370 Lancaster Avenue, Haverford, Pennsylvania 19041

Received 28 July 2008/ Accepted 2 November 2008

We demonstrate that enhanced lysozyme resistance of enteropathogenic Escherichia coli requires the plasmid-encoded regulator, Per, and is mediated by factors outside the locus for enterocyte effacement. EspC, a Per-activated serine protease autotransporter protein, conferred enhanced resistance on nonpathogenic E. coli, and a second Per-regulated, espC-independent lysozyme resistance mechanism was identified.

* Corresponding author. Mailing address: Department of Biology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041. Phone: (610) 896-1470. Fax: (610) 896-4963. E-mail: iokeke{at}haverford.edu

{triangledown} Published ahead of print on 7 November 2008.

Applied and Environmental Microbiology, January 2009, p. 275-280, Vol. 75, No. 1
0099-2240/09/$08.00+0     doi:10.1128/AEM.01734-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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