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Applied and Environmental Microbiology, June 2009, p. 3808-3812, Vol. 75, No. 11
0099-2240/09/$08.00+0     doi:10.1128/AEM.02496-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Diversification in the Quorum-Sensing System of Vibrio cholerae: Role of Natural Selection in the Emergence of Pandemic Strains{triangledown}

Nina M. Talyzina,1* Pär K. Ingvarsson,1 Jun Zhu,2 Sun N. Wai,3 and Agneta Andersson1

Department of Ecology and Environmental Science, Umeå University, SE-90187 Umeå, Sweden,1 Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,2 Department of Molecular Biology, Umeå University, SE-90187 Umeå, Sweden3

Received 31 October 2008/ Accepted 29 March 2009

Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.

* Corresponding author. Mailing address: Department of Ecology and Environmental Science, Umeå University, SE-90187 Umeå, Sweden. Phone: 46 (0)90 786 9845. Fax: 46 (0)90 786 6705. E-mail: nina.talyzina{at}emg.umu.se

{triangledown} Published ahead of print on 3 April 2009.

Applied and Environmental Microbiology, June 2009, p. 3808-3812, Vol. 75, No. 11
0099-2240/09/$08.00+0     doi:10.1128/AEM.02496-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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