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Applied and Environmental Microbiology, June 2009, p. 4194-4196, Vol. 75, No. 12
0099-2240/09/$08.00+0     doi:10.1128/AEM.00479-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Ferricrocin, a Siderophore Involved in Intra- and Transcellular Iron Distribution in Aspergillus fumigatus{triangledown} ,{dagger},{ddagger}

Anja Wallner,1 Michael Blatzer,1 Markus Schrettl,1 Bettina Sarg,2 Herbert Lindner,2 and Hubertus Haas1*

Division of Molecular Biology,1 Division of Clinical Biochemistry, Biocenter, Medical University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria2

Received 26 February 2009/ Accepted 5 April 2009

Iron is an essential metal for virtually all organisms. Iron acquisition is well characterized for various organisms, whereas intracellular iron distribution is poorly understood. In contrast to bacteria, plants, and animals, most fungi lack ferritin-mediated iron storage but possess an intracellular siderophore shown to be involved in iron storage. Here we demonstrate that deficiency in the intracellular siderophore ferricrocin causes iron starvation in conidia of Aspergillus fumigatus, demonstrating that ferricrocin is also involved in intra- and transcellular iron distribution. Thus, ferricrocin represents the first intracellular iron transporter identified in any organism.

* Corresponding author. Mailing address: Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria. Phone: 43-512-9003-70205. Fax: 43-512-9003-73100. E-mail: hubertus.haas{at}i-med.ac.at

{triangledown} Published ahead of print on 17 April 2009.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

{ddagger} The authors have paid a fee to allow immediate free access to this article.

Applied and Environmental Microbiology, June 2009, p. 4194-4196, Vol. 75, No. 12
0099-2240/09/$08.00+0     doi:10.1128/AEM.00479-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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