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Applied and Environmental Microbiology, July 2009, p. 4909-4912, Vol. 75, No. 14
0099-2240/09/$08.00+0     doi:10.1128/AEM.02478-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a-Producing Oscillatoria Cyanobacteria{triangledown} ,{dagger}

Sabrina Cadel-Six,1 Isabelle Iteman,1 Caroline Peyraud-Thomas,1 Stéphane Mann,2 Olivier Ploux,2 and Annick Méjean1,2,3*

Unité des Cyanobactéries (URA CNRS 2172), Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France,1 Laboratoire de Biochimie des Microorganismes: Enzymologie, Métabolisme et Antibiotiques (UMR CNRS 7223), ENSCP, 11 Rue Pierre et Marie Curie, 75231 Paris Cedex 05, France,2 Université Paris Diderot-Paris 7, 75013 Paris, France3

Received 29 October 2008/ Accepted 12 May 2009

We report the identification of a sequence from the genome of Oscillatoria sp. strain PCC 6506 coding for a polyketide synthase. Using 50 axenic cyanobacteria, we found this sequence only in the genomes of Oscillatoria strains producing anatoxin-a or homoanatoxin-a, indicating its likely involvement in the biosynthesis of these toxins.

* Corresponding author. Mailing address: Laboratoire de Biochimie des Microorganismes: Enzymologie, Métabolisme et Antibiotiques (UMR CNRS 7573), ENSCP, 11 Rue Pierre et Marie Curie, 75231 Paris Cedex 05, France. Phone and fax: 33 1 44 27 67 01. E-mail: annick-mejean{at}enscp.fr

{triangledown} Published ahead of print on 15 May 2009.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

Applied and Environmental Microbiology, July 2009, p. 4909-4912, Vol. 75, No. 14
0099-2240/09/$08.00+0     doi:10.1128/AEM.02478-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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